abstract：:FA ethyl esters (FAEE) are nonoxidative metabolites of ethanol produced by the esterification of FA and ethanol. FAEE have been implicated as mediators of ethanol-induced organ damage in vivo and in vitro, and are markers of ethanol intake. Upon ethanol intake, FAEE are synthesized in the liver and pancreas in signifi...

journal_title：Lipids

authors： Hasaba A,Cluette-Brown JE,Laposata M

更新日期：2003-10-01 00:00:00

abstract：:The tissue distribution of newly synthesized 22:6n-3 and intermediate PUFA was examined in rainbow trout to further our understanding of the metabolism of this EFA in fish. Rainbow trout were fed a pulse of deuterated linolenic acid (D5-17,17,18,18,18-18:3n-3), and the tissue distribution of deuterated anabolites was ...

journal_title：Lipids

authors： Bell MV,Dick JR,Porter AE

更新日期：2003-09-01 00:00:00

abstract：:Inflammatory disorders are associated with a decrease in iron absorption because of the blockade of iron in storage organs. Fish oils, rich in n-3 PUFA, are used to prevent and treat inflammatory disorders and increase iron absorption in noninflamed rats. Here we examine whether n-3 PUFA prevent inflammation-related h...

journal_title：Lipids

authors： Rodríguez MC,Sáiz MP,Mitjavila MT

更新日期：2003-08-01 00:00:00

abstract：:The FA composition of Fasciola hepatica 12 kDA purified native FA-binding protein (nFh12), a candidate vaccine against fascioliasis, is described. The FA chain lengths ranged between 12 and 24 carbons. The principal FA were 16:0, 18:1n-9, 18:0, 20:4n-6, and 20:1n-9. The acids 16:0, 18:1n-9, and 18:0 comprised over hal...

journal_title：Lipids

authors： Carballeira NM,Cruz H,Hillyer GV

更新日期：2003-07-01 00:00:00

abstract：:The effect of dietary n-3 FA deficiency on bone tissue FA composition was evaluated in growing rats. Two mixtures combining hydrogenated coconut oil with safflower oil served as the n-3-deficient dietary treatments and provided two levels of linoleic acid (LA). The n-3 treatments were formulated with added alpha-linol...

journal_title：Lipids

authors： Li Y,Greiner RS,Salem N Jr,Watkins BA

更新日期：2003-06-01 00:00:00

abstract：:This study investigated the influence of PUFA on the properties of mouse skin. Mice (3 wk old) were given free access to oils high in linoleic acid, CLA, or DHA for 4 wk. At the end of the experiment, their skins were compared by both biochemical and histological methods. No significant differences in lipid and collag...

journal_title：Lipids

authors： Oikawa D,Nakanishi T,Nakamura Y,Takahashi Y,Yamamoto T,Shiba N,Tobisa M,Takagi T,Iwamoto H,Tachibana T,Furuse M

更新日期：2003-06-01 00:00:00

abstract：:An experiment examined delta9 desaturase activity and FA composition in subcutaneous adipose tissue in two differing breeds of cattle. Jersey-sired cattle had significantly higher rates of desaturase activity than Limousin-sired cattle (1.55 vs. 0.75 nmol/mg protein/min). This difference was also demonstrated by a low...

journal_title：Lipids

authors： Siebert BD,Pitchford WS,Kruk ZA,Kuchel H,Deland MP,Bottema CD

更新日期：2003-05-01 00:00:00

abstract：:The reciprocal replacement of DHA by docosapentaenoic acid (DPAn-6) was studied in rats that consumed an n-3 FA-deficient or n-3 FA-adequate diet. Dams were fed the two experimental diets from weaning and throughout pregnancy and lactation. Their pups were then fed the respective diets after weaning. Cortex FA analysi...

journal_title：Lipids

authors： Greiner RS,Catalan JN,Moriguchi T,Salem N Jr

更新日期：2003-04-01 00:00:00

abstract：:The purpose of this study was to compare fish intake and plasma phospholipid concentrations of n-3 fatty acids, in particular of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among representative population samples of Québecers, James Bay Cree, and Inuit of Nunavik (Canada). The relationships between the...

journal_title：Lipids

authors： Dewailly E,Blanchet C,Gingras S,Lemieux S,Holub BJ

更新日期：2003-04-01 00:00:00

abstract：:The aim of the present study was to develop a cell culture system for studying the proliferation and differentiation of preadipocytes isolated from Atlantic salmon adipose tissue. The expression of proliferating cell nuclear antigen (PCNA) was used as a marker for cell proliferation. The cells started to proliferate w...

journal_title：Lipids

authors： Vegusdal A,Sundvold H,Gjøen T,Ruyter B

更新日期：2003-03-01 00:00:00

abstract：:The kinetics of in vivo clearance of apolipoprotein (apo) A-I radioiodinated by the iodine monochloride (ICI) method of McFarlane [McFarlane, A.S. (1958) Efficient Trace-Labelling of Proteins with Iodine, Nature 182, 53] as modified by Bilheimer and co-workers [Bilheimer, D.W., Eisenberg, S., and Levy, R.I. (1972) The...

journal_title：Lipids

authors： Zhang B,Shimoji E,Tanaka H,Saku K

更新日期：2003-03-01 00:00:00

abstract：:Previous research in rats and mice has suggested that gamma-linolenic acid (GLA) derived from borage oil (BO: 23% GLA) may be an appropriate source for increasing levels of long-chain n-6 FA in the developing brain. Recently, transgenic technology has made available a highly enriched GLA seed oil from the canola plant...

journal_title：Lipids

authors： Wainwright PE,Huang YS,DeMichele SJ,Xing H,Liu JW,Chuang LT,Biederman J

更新日期：2003-02-01 00:00:00

abstract：:Obesity and type 2 diabetes have reached epidemic proportions in the United States. It is well-established that increasing physical activity plays an important role in reducing risk of obesity and diabetes. Few studies, however, have examined the association between sedentary behaviors such as prolonged television (TV...

journal_title：Lipids

authors： Hu FB

更新日期：2003-02-01 00:00:00

abstract：:To address the role of cell membrane neutral sphingomyelinase (EC 3.1.4.12; SMase) in the regulation of cholesterol metabolism in the liver parenchymal cell, we examined the effect of exogenous neutral SMase on the metabolism of cholesteryl esters and the secretion of VLDL and biliary lipids in isolated rat hepatocyte...

journal_title：Lipids

authors： Liza M,Chico Y,Fresnedo O,Ochoa B

更新日期：2003-01-01 00:00:00

abstract：:A ubiquitously expressed member of the cytochrome P450 superfamily, CYP51, encodes lanosterol 14alpha-demethylase, the first step in the conversion of lanosterol into cholesterol in mammals. The biosynthetic intermediates of lanosterol 14alpha-demethylation are oxysterols, which inhibit HMG-CoA reductase and sterol sy...

journal_title：Lipids

authors： Gibbons GF

更新日期：2002-12-01 00:00:00

abstract：:A simple method for the determination of bile acids in adult human fecal samples using GC-MS is described. Bile acids are directly extracted from feces by ethanol (95%) containing 0.1 N NaOH. Extracts are purified by passage through a reversed-phase C18 silica cartridge and then analyzed by GC-MS. The present study ha...

journal_title：Lipids

authors： Perwaiz S,Mignault D,Tuchweber B,Yousef IM

更新日期：2002-11-01 00:00:00

abstract：:CLA mixtures are now commercially available. They differ from each other with respect to their content of CLA isomers and their degree of purification. As a group of natural FA, CLA have been widely assumed to be safe. However, the suspected presence of both impurities and particular isomers might induce undesirable s...

journal_title：Lipids

authors： Gaullier JM,Berven G,Blankson H,Gudmundsen O

更新日期：2002-11-01 00:00:00

abstract：:Hydrolysis of symmetrical acetylenic TG of type AAA [viz., glycerol tri-(4-decynoate), glycerol tri-(6-octadecynoate), glycerol tri-(9-octadecynoate), glycerol tri-(10-undecynoate), and glycerol tri-(13-docosynoate)] in the presence of eight microbial lipases was studied. Novozyme 435 (Candida antarctica), an efficien...

journal_title：Lipids

authors： Jie MS,Fua X,Lau MM,Chye ML

更新日期：2002-10-01 00:00:00

abstract：:Pycnogenol (PYC), an extract of French maritime pine bark (Pinus pinaster), is a potent antioxidant with potential health benefits. Its bioavailabilty has previously been shown by urinary excretion studies of constituents and metabolites of PYC. The aim of this study was to test the effect of PYC supplementation on me...

journal_title：Lipids

authors： Devaraj S,Vega-López S,Kaul N,Schönlau F,Rohdewald P,Jialal I

更新日期：2002-10-01 00:00:00

abstract：:This work reports the effect of the apolipoproteins A-I and A-II (apoA-I and apoA-II) on the release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-8, and IL-1 receptor antagonist (IL-1Ra) and on the oxidative burst of human neutrophils. By themselves, apoA-I and apoA-II do not affect the basal liber...

journal_title：Lipids

authors： Furlaneto CJ,Ribeiro FP,Hatanaka E,Souza GM,Cassatella MA,Campa A

更新日期：2002-09-01 00:00:00

abstract：:CLA inhibits mammary cancer and reduces body fat accumulation in rodents. It is not known whether uncoupling proteins (UCP), which are modulators of energy balance and metabolism, play a role in these actions of CLA. To determine the effects of dietary CLA on the expression of UCP in various tissues, 5-wk-old Sprague-...

journal_title：Lipids

authors： Ealey KN,El-Sohemy A,Archer MC

更新日期：2002-09-01 00:00:00

abstract：:Oxidized LDL (oxLDL) may contribute to the accumulation of apoptotic cells in atherosclerotic plaques. Although it is well established in monophasic chemical systems that the highly unsaturated EPA and DHA will oxidize more readily than FA that contain fewer double bonds, our previous studies showed that enrichment of...

journal_title：Lipids

authors： Wu T,Geigerman C,Lee YS,Wander RC

更新日期：2002-08-01 00:00:00

abstract：:CLA has a range of biological properties, including effects on lipid metabolism and body composition in experimental animals. The prevalent isomer of CLA found in the human diet is 9c,11 t-CLA, and it is predominantly found in products containing fat from ruminant animals. This study investigated the effect of dietary...

journal_title：Lipids

authors： Hayman A,MacGibbon A,Pack RJ,Rutherfurd K,Green JH

更新日期：2002-07-01 00:00:00

abstract：:The content and positional distribution of CLA in TAG fractions of lamb tissues was examined with either preformed CLA or the linoleic acid precursor of CLA in the diet as experimental treatments. The CLA content of phospholipid (PL) from these tissues was also examined. Thirteen lambs were randomized to the following...

journal_title：Lipids

authors： Paterson LJ,Weselake RJ,Mir PS,Mir Z

更新日期：2002-06-01 00:00:00

abstract：:The initial steps in the autoxidation of CLA methyl ester are poorly understood. The aim of this study was to determine the stereochemistry of the hydroperoxides formed during autoxidation of CLA methyl ester in the presence of a good hydrogen atom donor. For this purpose, 9-cis,11-trans CLA methyl ester was autoxidiz...

journal_title：Lipids

authors： Hämäläinen TI,Sundberg S,Hase T,Hopia A

更新日期：2002-06-01 00:00:00

abstract：:The effects of dietary stearidonic acid (18:4n-3) on inflammatory mediator release in whole blood and splenocytes was investigated in Balb/c mice, and the effects were compared with those of two other n-3 PUFA: alpha-linolenic acid (18:3n-3) and EPA (20:5n-3). TAG mixtures containing 10% of 18:4n-3, 18:3n-3, or 20:5n-...

journal_title：Lipids

authors： Ishihara K,Komatsu W,Saito H,Shinohara K

更新日期：2002-05-01 00:00:00

abstract：:The effects of SMP-500, a novel ACAT inhibitor, on serum lipid levels, hepatic lipid secretion rate, and hepatic lipid disposition in rats were studied to clarify its lipid-lowering action. SMP-500 reduced the serum cholesterol level in a dose-dependent manner in rats fed a hypercholesterolemic diet. SMP-500 also redu...

journal_title：Lipids

authors： Ioriya K,Nishimura T,Ohashi N

更新日期：2002-04-01 00:00:00

abstract：:There have been a limited number of studies investigating surfactant lipid changes in lung with trace elements. The present investigation was designed to examine the effect of moderate zinc deficiency on the lipid metabolism in rat lung. We also evaluated whether zinc deficiency, which is a wide-spread problem, could ...

journal_title：Lipids

authors： Gomez NN,Ojeda MS,Gimenez MS

更新日期：2002-03-01 00:00:00

abstract：:Mevalonic acid-derived intermediates in the cholesterol biosynthetic pathway have been recognized as being critical to the isoprenylation of a variety of growth-regulating proteins, including those of the RAS superfamily. Treatment of cells with lovastatin, a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibi...

journal_title：Lipids

authors： Ownby SE,Hohl RJ

更新日期：2002-02-01 00:00:00

abstract：:Fourteen pairs of obese female monozygotic twins were recruited for a study of genetic influences on serum and adipose fatty acid (FA) composition. Following 1 wk of inpatient stabilization, fasting serum and adipose tissue obtained by surgical excision were analyzed by thin-layer and gas chromatography. Intrapair res...

journal_title：Lipids

authors： Kunesová M,Hainer V,Tvrzicka E,Phinney SD,Stich V,Parízková J,Zák A,Stunkard AJ

更新日期：2002-01-01 00:00:00

abstract：:Fatty acids of Ophiuroidea (brittle star) Ophiura sarsi have been investigated by gas-liquid chromatography (GLC). About 2-13% of four unidentified fatty acids were found in total fatty acids from a sample caught at a depth of 1,100 m. Structural analyses were undertaken after partial hydrogenation of their concentrat...

journal_title：Lipids

authors： Sato D,Ando Y,Tsujimoto R,Kawasaki K

更新日期：2001-12-01 00:00:00

abstract：:Lipophilic toxins have been introduced into the environment both as functional compounds, such as pesticides, and as industrial waste from incineration or the manufacture of electrical transformer components. Among these substances are compounds that are carcinogenic and that affect the endocrine system. Accidental hi...

journal_title：Lipids

authors： Jandacek RJ,Tso P

更新日期：2001-12-01 00:00:00

abstract：:The molecular species in mixtures of phospholipid hydroperoxides are difficult to separate and identify by typical chromatographic and mass spectrometric techniques. As reported by Havrilla and coworkers, silver ion coordination ion-spray mass spectrometry (CIS-MS) has proven to be a powerful technique for the identif...

journal_title：Lipids

authors： Milne GL,Porter NA

更新日期：2001-11-01 00:00:00

abstract：:Greatly increasing the amounts of flaxseed oil [rich in alpha-linolenic acid (ALNA)] or fish oil (FO); [rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] in the diet can decrease inflammatory cell functions and so might impair host defense. The objective of this study was to determine the effect of d...

journal_title：Lipids

authors： Thies F,Miles EA,Nebe-von-Caron G,Powell JR,Hurst TL,Newsholme EA,Calder PC

更新日期：2001-11-01 00:00:00

abstract：:Rainbow trout (Oncorhynchus mykiss) weighing ca. 5 g and previously acclimated for 8 wk on a diet comprising vegetable oil (11%), fish meal (5%), and casein (48%) as the major constituents were fed a pulse of diet containing deuterated (D5) (17,17,18,18,18)-18:3n-3 ethyl ester. The synthesis and tissue distribution of...

journal_title：Lipids

authors： Bell MV,Dick JR,Porter AE

更新日期：2001-10-01 00:00:00

abstract：:New methods and analytical approaches are important to challenge and/or validate established beliefs in any field including the metabolism of polyunsaturated fatty acids (PUFA; polyunsaturates). Four methods that have recently been applied toward obtaining a better understanding of the homeostasis of PUFA include the ...

journal_title：Lipids

authors： Cunnane SC

更新日期：2001-09-01 00:00:00

abstract：:Essential fatty acids are structural components of all tissues and are indispensable for cell membrane synthesis; the brain, retina and other neural tissues are particularly rich in long-chain polyunsaturated fatty acids (LC-PUFA). These fatty acids serve as specific precursors for eicosanoids, which regulate numerous...

journal_title：Lipids

authors： Uauy R,Hoffman DR,Peirano P,Birch DG,Birch EE

更新日期：2001-09-01 00:00:00

abstract：:Two per thousand pregnant women have hyperthyroidism (HT), and although the symptoms are attenuated during pregnancy, they rebound after delivery, affecting infant development. To examine the effects of hyperthyroidism on lactation, we studied lipid metabolism in maternal mammary glands and livers of hyperthyroid rats...

journal_title：Lipids

authors： Varas SM,Jahn GA,Giménez MS

更新日期：2001-08-01 00:00:00

abstract：:The degradation of alpha-tocopherol and the formation of alpha-tocopherol and triacylglycerol oxidation products at high temperatures (150-250 degrees C) over a heating period (0-4 h) for a model system ranging between triolein and tripalmitin were modeled by use of an experimental design. The oxidation products of al...

journal_title：Lipids

authors： Verleyen T,Kamal-Eldin A,Dobarganes C,Verhe R,Dewettinck K,Huyghebaert A

更新日期：2001-07-01 00:00:00

abstract：:Some 1,2- and 1,3-diacyl glycerols (with acyl groups as stearyl, oleyl, linoleyl, or stearolyl) were synthesized by conventional methods. The diacyl glycerols were esterified with 6-bromo-hexanoic acid to give the corresponding bromo-triacylglycerols (of the type AAB and ABA containing a bromo group at the distal part...

journal_title：Lipids

authors： Jie MS,Cheung SW,Ho JC

更新日期：2001-06-01 00:00:00